Nutridom Bromelain 500 mg 60 Vcaps

$0.00

– Free from: GMO, Radiation.
– 2400 GDU/g, 1.8 x 107 FCC PU (papain units) per capsule.
– One of the highest potency bromelain enzyme product available.

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PRODUCT RESEARCH / SAFETY

Digestive Enzyme Bromelain



Bromelain is an enzyme found in pineapple juice and in the pineapple stem. Pineapple has been used for centuries in Central and South America to treat indigestion and reduce inflammation. Along with papain, bromelain is one of the most popular proteases used to tenderize meat. Bromelain is a proteolytic enzyme that breaks down proteins into various amino acids during digestion. It also has superior anti-inflammatory properties, and immune system modulating properties.
There are many ways the enzyme activity of bromelain can be measured. The most commonly used and standard ways are: GDU (gelatin digesting units), MCU (milk clotting units), and FCC PU (papain unit). This measurement is based on how much one gram of the enzyme will digest. The higher GDU, MCU, and FCC PY is, the greater the enzyme activity. One FCC Papain Unit (PU) is defined as that quantity of enzyme that liberates the equivalent of 1mcg of tyrosine per hour under the conditions of the assay. This procedure is sometimes used to determine the proteolytic activity of bromelain. The assay is based on a 60-minute proteolytic hydrolysis of a casein substrate at pH 6.0 and 40° C. If you are looking at different products trying to determine which product has superior enzyme activity, just remember the following conversion unit!
1 GDU= 1.5 MCU= 15,000 FCC HUT.

Bromelain and anti-inflammation



The clinical study by Ordesi et al. (2014) demonstrates anti-inflammatory and anti-edematous effect of bromelain. In the group of patients who were prescribed bromelain after surgery, the inflammatory response was significantly less than in the control group. Similarly, a clinical study by Majid and Al-Mashhadani (2014) also shows that oral bromelain is an effective therapy to improve the quality of life and reduction in pain after surgery compared to the placebo group.

Bromelain digests proteins



Bromelain is a proteolytic enzyme that breaks down proteins. For this reason, it is often used as a digestive aid and to treat muscle injuries. What makes bromelain particularly effective is the fact that it is vegetarian digestive enzyme. Plant-based enzymes are active across a wide pH range, which makes them useful for aiding digestion in the low pH of the stomach as well as the moderately high-pH environment of the intestine. Insufficient digestion in the mouth and stomach means the small intestine must work harder to break down and absorb food molecules. This imbalance often causes digestive discomfort including bloating, gas, and constipation.

Caution



Take with meal. Consult a health care practitioner prior to use if you are pregnant or breastfeeding; if you have a gastrointestinal lesion/ulcer; if you are are taking an anticoagulant/ blood thinner, anti-inflammatory or antibiotic; or if you are having surgery. Hypersensitivity/allergy has been known to occur; in which case, discontinue use. Nausea, vomiting, and diarrhoea have been known to occur, in which case discontinue use. For prolonged use, consult a health care practitioner.

REFERENCES

    • Hale LP, Greer PK, Sempowski GD. Bromelain treatment alters leukocyte expression of cell surface molecules involved in cellular adhesion and activation. Clin Immunol 2002;104:183-90.
    • Brien S, Lewith G, Walker AF, et al. Bromelain as an adjunctive treatment for moderate-to-severe osteoarthritis of the knee: a randomized placebo-controlled pilot study. QJM 2006;99:841-50.
    • Lotz-Winter, H. On the pharmacology of bromelain: an update with special regard to animal studies on dose-dependent effects. Planta Med 1990;56(3):249-253
    • Ordesi P, Pisoni L, Nannei P, Macchi M, Borloni R, and Siervo S. Therapeutic efficacy of bromelain in impacted third molar surgery: a randomized controlled clinical study. Quintessence Int. 2014 Sep;45(8):679-84.

IOM 2006: Institute of Medicine. Otten JJ, Pitzi Hellwig J, Meyers LD, editors. Institute of Medicine. Dietary Reference Intakes: The Essential Guide to Nutrient Requirements. Washington (DC): National Academies Press; 2006.

  • Majid OW, and Al-Mashhadani BA. Perioperative bromelain reduces pain and swelling and improves quality of life measures after mandibular third molar surgery: a randomized, double-blind, placebo-controlled clinical trial. J Oral Maxillofac Surg. 2014 Jun;72(6):1043-8.



This page is not intended to be a comprehensive review of the medicinal ingredient.

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